Depression and metabolism: linking changes in leptin and ghrelin to mood
نویسندگان
چکیده
Major depressive disorder is associated with an elevated risk of numerous metabolic disturbances, including obesity, metabolic syndrome, insulin-dependent diabetes mellitus type II, and death after myocardial infarction. Several recent papers also indicate that disturbances of mood may alter peripheral signaling pathways that regulate metabolic processes, including those involving leptin and ghrelin.
منابع مشابه
Evaluation of Ghrelin and Leptin in Patients with Thyroid Malfunction
Introduction: Leptin and Ghrelin are hormones that have been discovered in the last decade and were shown to be involved in appetite and metabolism regulation and body weight. Thyroid hormones are also involved in general metabolism and changes in their circulating levels bring about changes in appetite and body weight. Results of animal and human studies regarding Leptinlevel and its re...
متن کاملEffect of ICV injection of ghrelin and leptin on T3 and T4 plasma levels in Rat
Introduction: Ghrelin, increases food intake, decreases T3 and T4 concentrations and stimulates insulin release, while leptin reduces food intake and suppresses appetite. Considering the importance of thyroid hormones, ghrelin and leptin in body metabolism, the purpose of this study was to investigate the effect of interactions between ghrelin and leptin (injected via ICV route) and plasma T...
متن کاملSerum Ghrelin and Leptin Levels in Patients with Depression and the Effects of Treatment
OBJECTIVE Ghrelin and leptin, appetite-regulating hormones, play a role in mood regulation. Current data about the relation between leptin/ghrelin and depression are still controversial. This study aimed to investigate serum leptin and ghrelin levels in patients with depression and the effects of treatment on these levels. METHODS Serum ghrelin and leptin levels were measured before and after...
متن کاملGut feelings about depression.
The perspective that eating and obesity are linked to depressive disorders has gained considerable purchase, in part, because of the attention devoted to obesity in general, the finding that obesity is accompanied by a 25% increase of anxiety and depressive disorders, and because of reports linking obesity and depression to heart disease1 as well as other conditions that involve inflammatory fa...
متن کاملEffects of Zinc Supplementation on the Anthropometric Measurements, Leptin, Ghrelin and C-reactive protein in the Obese Adults with Increased Appetite and Baseline Zinc Deficiency: A Randomized Controlled Trial
Background: Appetite is one of the main obesity-controlling factors that can be influenced by hormones, including leptin and ghrelin. This study aimed to determine the effects of zinc supplementation on the serum levels of leptin, ghrelin, C-reactive protein (CRP), and anthropometrical indices in obese individuals with increased appetite and zinc deficiency. Methods: This study was conducted a...
متن کامل